The average train between Florence and Mendrisio takes 3h 38m and the fastest train takes 3h 16m. There is a train service every few hours from Florence to Mendrisio. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Florence and Mendrisio. The earliest departure is at 7:25 AM in the morning, and the last departure from Florence is at 9:25 PM which arrives into Mendrisio at 6:41 AM. All services require a transfer, and take on average 3h 38m. The schedules shown below are for the next available departures.

3h 16m • 1 change

3h 16m • 1 change

3h 16m • 1 change

3h 16m • 1 change

3h 16m • 1 change

3h 16m • 1 change

3h 16m • 1 change

3h 16m • 1 change

3h 16m • 1 change

3h 16m • 1 change

3h 16m • 1 change

3h 16m • 1 change

3h 16m • 1 change

3h 16m • 1 change

3h 16m • 1 change

3h 16m • 1 change
Want to know about travelling from Florence to Mendrisio? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Florence to Mendrisio. However, there are services departing from Florence station and arriving at Mendrisio station via Milano Centrale. The journey, including transfers, takes approximately 3h 38m.
Florence to Mendrisio train services, operated by ItaloTreno, depart from Firenze Santa Maria Novella station.
Florence to Mendrisio train services, operated by ItaloTreno, arrive at Mendrisio station.
The distance between Florence and Mendrisio is 292.9 km. The road distance is 362 km.
You can take a train from Firenze Santa Maria Novella to Mendrisio via Milano Centrale in around 3h 29m.