The average train between Florence and Mesagne takes 13h 42m and the fastest train takes 9h 15m. The train service runs several times per day from Florence to Mesagne. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run twice daily between Florence and Mesagne. The earliest departure is at 7:43 AM in the morning, and the last departure from Florence is at 8:28 PM which arrives into Mesagne at 2:16 PM. All services require a transfer at Brindisi and take an average of 13h 42m. The schedules shown below are for the next available departures.


9h 15m • 2 changes
Arrives next day


14h 57m • 2 changes
Arrives next day


17h 48m • 2 changes


9h 15m • 2 changes
Arrives next day


14h 57m • 2 changes
Arrives next day


17h 48m • 2 changes
Arrives next day


14h 57m • 2 changes
Arrives next day


17h 48m • 2 changes


9h 15m • 2 changes
Arrives next day


14h 57m • 2 changes
Arrives next day


17h 48m • 2 changes
Want to know about travelling from Florence to Mesagne? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Florence to Mesagne. However, there are services departing from Florence station and arriving at Mesagne station via Brindisi. The journey, including transfers, takes approximately 13h 42m.
Florence to Mesagne train services, operated by ItaloTreno, depart from Firenze S.M.N. station.
Florence to Mesagne train services, operated by ItaloTreno, arrive at Brindisi station.
Book your Florence to Mesagne train tickets online with ItaloTreno, Trenitalia Frecce and Trenitalia.
The distance between Florence and Mesagne is 648.3 km. The road distance is 867 km.
Trenitalia Frecce operates a train from Firenze S.M.N. to Brindisi twice daily. Tickets cost €120–250 and the journey takes 7h 14m.