The average train between Florence and Sant'Antimo takes 4h and the fastest train takes 3h 21m. There is a train service every few hours from Florence to Sant'Antimo. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Florence and Sant'Antimo. The earliest departure is at 6:00 AM in the morning, and the last departure from Florence is at 8:48 PM which arrives into Sant'Antimo at 5:17 AM. All services require a transfer, and take on average 4h. The schedules shown below are for the next available departures.

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3h 46m • 1 changeWant to know about travelling from Florence to Sant'Antimo? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Florence to Sant'Antimo. However, there are services departing from Firenze S.M.N. station and arriving at Napoli Centrale station via Napoli Centrale station. The journey, including transfers, takes approximately 4h.
Florence to Sant'Antimo train services, operated by Trenitalia Frecce, depart from Firenze S.M.N. station.
Florence to Sant'Antimo train services, operated by Trenitalia Frecce, arrive at Napoli Centrale station.
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The distance between Florence and Sant'Antimo is 399.7 km. The road distance is 460 km.
Trenitalia Frecce operates a train from Firenze S.M.N. to Napoli Centrale hourly. Tickets cost €65–110 and the journey takes 3h 5m. ItaloTreno also services this route 5 times a day.