The average train between Florence and Sant'Antimo takes 4h 6m and the fastest train takes 3h 22m. The train service runs several times per day from Florence to Sant'Antimo. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 2 hours between Florence and Sant'Antimo. The earliest departure is at 7:43 AM in the morning, and the last departure from Florence is at 7:43 PM which arrives into Sant'Antimo at 4:22 AM. All services require a transfer, and take on average 4h 6m. The schedules shown below are for the next available departures.

3h 57m • 1 change

4h 3m • 1 change
Arrives next day

8h 39m • 1 change

3h 33m • 1 change

3h 30m • 1 change

3h 32m • 1 change

3h 40m • 1 change

3h 33m • 1 change

3h 30m • 1 change

3h 32m • 1 change

3h 40m • 1 change

3h 53m • 1 change

3h 40m • 1 change

3h 57m • 1 change

4h 8m • 1 change

3h 53m • 1 change

3h 40m • 1 change

3h 57m • 1 change

4h 8m • 1 change

3h 33m • 1 change

3h 30m • 1 change

3h 32m • 1 change

3h 40m • 1 change
Want to know about travelling from Florence to Sant'Antimo? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Florence to Sant'Antimo. However, there are services departing from Florence station and arriving at Sant'Antimo station via Napoli. The journey, including transfers, takes approximately 4h 6m.
Florence to Sant'Antimo train services, operated by ItaloTreno, depart from Firenze Santa Maria Novella station.
Florence to Sant'Antimo train services, operated by ItaloTreno, arrive at Napoli station.
Book your Florence to Sant'Antimo train tickets online with ItaloTreno and Trenitalia.
The distance between Florence and Sant'Antimo is 399.7 km. The road distance is 489 km.
ItaloTreno operates a train from Firenze Santa Maria Novella to Napoli every 30 minutes. Tickets cost €60–120 and the journey takes 3h.