The average train between Florence and Sant'Antimo takes 4h 3m and the fastest train takes 3h 32m. There is a train service every few hours from Florence to Sant'Antimo. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Florence and Sant'Antimo. The earliest departure is at 6:00 AM in the morning, and the last departure from Florence is at 8:48 PM which arrives into Sant'Antimo at 4:22 AM. All services require a transfer, and take on average 4h 3m. The schedules shown below are for the next available departures.

3h 49m • 1 change
3h 46m • 1 change
3h 46m • 1 change
3h 38m • 1 change
4h • 1 change
4h 59m • 1 change
3h 46m • 1 change
3h 35m • 1 change
4h 22m • 1 change
4h 9m • 1 change
3h 41m • 1 change
3h 48m • 1 change
4h • 1 change
4h 2m • 1 change
3h 46m • 1 change
3h 36m • 1 changeWant to know about travelling from Florence to Sant'Antimo? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Florence to Sant'Antimo. However, there are services departing from Florence station and arriving at Sant'Antimo station via Napoli Centrale. The journey, including transfers, takes approximately 4h 3m.
Florence to Sant'Antimo train services, operated by Trenitalia Frecce, depart from Firenze S.M.N. station.
Florence to Sant'Antimo train services, operated by Trenitalia Frecce, arrive at Napoli Centrale station.
Book your Florence to Sant'Antimo train tickets online with Trenitalia Frecce and Trenitalia.
The distance between Florence and Sant'Antimo is 399.7 km. The road distance is 489 km.
Trenitalia Frecce operates a train from Firenze S.M.N. to Napoli Centrale hourly. Tickets cost €65–130 and the journey takes 3h 5m. ItaloTreno also services this route 5 times a day.