The average train between Florence and Sesto Calende takes 4h 56m and the fastest train takes 3h 7m. The train service runs several times per day from Florence to Sesto Calende. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 4 hours between Florence and Sesto Calende. The earliest departure is at 7:25 AM in the morning, and the last departure from Florence is at 8:25 PM which arrives into Sesto Calende at 7:04 AM. All services require a transfer, and take on average 4h 56m. The schedules shown below are for the next available departures.

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4h 7m • 1 changeWant to know about travelling from Florence to Sesto Calende? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Florence to Sesto Calende. However, there are services departing from Firenze Santa Maria Novella station and arriving at Sesto Calende station via Milano Rogoredo station. The journey, including transfers, takes approximately 4h 56m.
Florence to Sesto Calende train services, operated by ItaloTreno, depart from Firenze Santa Maria Novella station.
Florence to Sesto Calende train services, operated by Trenitalia, arrive at Sesto Calende station.
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The distance between Florence and Sesto Calende is 298.8 km. The road distance is 353 km.
You can take a train from Firenze Santa Maria Novella to Sesto Calende via Rho-Fiera Milano in around 3h 18m.