Florence to Sistine Chapel Trains

Florence to Sistine Chapel trains

Travel from

Search accommodation with Expedia

Trip Overview

The average train between Florence and Sistine Chapel takes 1h 59m and the fastest train takes 1h 45m. The train runs at least 2 times per hour from Florence to Sistine Chapel. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

1h 59m
Duration: 268 km
Distance: €39
Average price: Every 30 minutes
Frequency

Train

best

Take the train from Firenze S.M.N. to Roma Terminitrain Fr

2h 12m

€30–62

Florence to Sistine Chapel train times

Trains run every 30 minutes between Florence and Sistine Chapel. The earliest departure is at 6:00 AM in the morning, and the last departure from Florence is at 10:14 PM which arrives into Sistine Chapel at 6:03 AM. All services require a transfer at Rome Termini and take an average of 1h 59m. The schedules shown below are for the next available departures.

Departing Thursday, October 29, 2026

5:14 PM → 7:08 PM
1h 54m • 1 change
5:48 PM → 7:40 PM
1h 52m • 1 change
5:59 PM → 7:55 PM
1h 56m • 1 change
6:14 PM → 8:05 PM
1h 51m • 1 change
Show more

Departing Friday, October 30, 2026

6:00 AM → 8:39 AM
2h 39m • 1 change
7:05 AM → 8:51 AM
1h 46m • 1 change
7:14 AM → 9:20 AM
2h 6m • 1 change
7:48 AM → 9:58 AM
2h 10m • 1 change
Show more

Departing Saturday, October 31, 2026

6:00 AM → 8:40 AM
2h 40m • 1 change
7:05 AM → 8:51 AM
1h 46m • 1 change
7:14 AM → 9:20 AM
2h 6m • 1 change
7:48 AM → 9:53 AM
2h 5m • 1 change
Show more

Departing Sunday, November 1, 2026

7:05 AM → 8:55 AM
1h 50m • 1 change
7:14 AM → 9:19 AM
2h 5m • 1 change
7:48 AM → 9:48 AM
2h • 1 change
7:59 AM → 9:55 AM
1h 56m • 1 change
Show more

Departing Monday, November 2, 2026

6:00 AM → 8:39 AM
2h 39m • 1 change
7:05 AM → 8:54 AM
1h 49m • 1 change
7:14 AM → 9:20 AM
2h 6m • 1 change
7:48 AM → 9:47 AM
1h 59m • 1 change
Show more

Departing Tuesday, November 3, 2026

6:00 AM → 8:39 AM
2h 39m • 1 change
7:05 AM → 8:54 AM
1h 49m • 1 change
7:14 AM → 9:20 AM
2h 6m • 1 change
7:48 AM → 9:47 AM
1h 59m • 1 change
Show more

Departing Wednesday, November 4, 2026

6:00 AM → 8:39 AM
2h 39m • 1 change
7:05 AM → 8:54 AM
1h 49m • 1 change
7:14 AM → 9:20 AM
2h 6m • 1 change
7:48 AM → 9:47 AM
1h 59m • 1 change
Show more

Frequently asked questions

Want to know about travelling from Florence to Sistine Chapel? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

What companies run services between Florence, Italy and Sistine Chapel, Vatican City?

Trenitalia Frecce operates a train from Firenze S.M.N. to Roma Termini every 30 minutes. Tickets cost €35–65 and the journey takes 1h 36m. Three other operators also service this route.

Operators