The average train between Florence and Sistine Chapel takes 2h 1m and the fastest train takes 1h 46m. The train runs at least 2 times per hour from Florence to Sistine Chapel. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 30 minutes between Florence and Sistine Chapel. The earliest departure is at 6:00 AM in the morning, and the last departure from Florence is at 10:14 PM which arrives into Sistine Chapel at 6:03 AM. All services require a transfer at Rome Termini and take an average of 2h 1m. The schedules shown below are for the next available departures.

2h 39m • 1 change
1h 49m • 1 change
2h 6m • 1 change
2h 6m • 1 changeWant to know about travelling from Florence to Sistine Chapel? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Florence to Sistine Chapel. However, there are services departing from Florence station and arriving at Sistine Chapel station via Roma Termini. The journey, including transfers, takes approximately 2h 1m.
Florence to Sistine Chapel train services, operated by Trenitalia Frecce, depart from Firenze S.M.N. station.
Florence to Sistine Chapel train services, operated by Trenitalia Frecce, arrive at Roma Termini station.
The distance between Florence and Sistine Chapel is 230.7 km. The road distance is 268 km.
Trenitalia Frecce operates a train from Firenze S.M.N. to Roma Termini every 30 minutes. Tickets cost €35–75 and the journey takes 1h 36m. Two other operators also service this route.