Rome2Rio

Florence to Frederick trains

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Trip Overview

The average train between Florence and Frederick takes 21h 16m and the fastest train takes 18h 57m. The train runs, on average, 5 times per week from Florence to Frederick. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

21h 16m
Duration
463 mi
Distance
$275
Average price
5 times a week
Frequency

Florence to Frederick train times

Trains run 5 times a week between Florence and Frederick. The earliest departure is at 10:54 AM in the morning, and the last departure from Florence is at 10:32 PM which arrives into Frederick at 5:29 PM. All services require a transfer, and take on average 21h 16m. The schedules shown below are for the next available departures.

Departing Tuesday, November 10, 2026

  •  → 

    Arrives next day

    AmtrakMaryland Transit30h 35m • 1 change

Departing Wednesday, November 11, 2026

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    Arrives next day

    AmtrakMaryland Transit18h 57m • 1 change

Departing Thursday, November 12, 2026

  •  → 

    Arrives next day

    AmtrakMaryland Transit18h 57m • 1 change

Departing Sunday, November 15, 2026

  •  → 

    Arrives next day

    AmtrakMaryland Transit18h 57m • 1 change

Departing Monday, November 16, 2026

  •  → 

    Arrives next day

    AmtrakMaryland Transit18h 57m • 1 change

Frequently asked questions

Want to know about travelling from Florence to Frederick? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Florence to Frederick.ExpandLaunch map view
  • Distance: 463.1 mi
  • Duration: 21h 16m

What companies run services between Florence, SC, USA and Frederick, MD, USA?

You can take a train from Florence Station to FREDERICK MARC wb via Washington Union Station in around 10h 57m.

Operators