The average train between Frankfurt - Main Bus Station and Prague takes 8h 18m and the fastest train takes 7h 24m. The train service runs several times per day from Frankfurt - Main Bus Station to Prague. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 4 hours between Frankfurt - Main Bus Station and Prague. The earliest departure is at 4:54 AM at night, and the last departure from Frankfurt - Main Bus Station is at 8:57 PM which arrives into Prague at 10:21 AM. All services require a transfer at Nürnberg Hbf and take an average of 8h 18m. The schedules shown below are for the next available departures.


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Want to know about travelling from Frankfurt - Main Bus Station to Prague? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Frankfurt - Main Bus Station to Prague. However, there are services departing from Frankfurt - Main Bus Station station and arriving at Prague station via Nürnberg Hbf. The journey, including transfers, takes approximately 8h 18m.
Frankfurt - Main Bus Station to Prague train services, operated by Deutsche Bahn Intercity (DB IC), depart from Frankfurt station.
Frankfurt - Main Bus Station to Prague train services, operated by Deutsche Bahn Intercity (DB IC), arrive at Praha Hlavni Nadrazi station.
Book your Frankfurt - Main Bus Station to Prague train tickets online with Deutsche Bahn Intercity (DB IC), Deutsche Bahn Regio (DB Regional) and Die Länderbahn.
The distance between Frankfurt - Main Bus Station and Prague is 410.6 km. The road distance is 564 km.
You can take a train from Frankfurt to Praha Hlavni Nadrazi via Nürnberg Hbf and Schwandorf in around 8h 9m.