The average train between Frankfurt South Station and Prague takes 8h 41m and the fastest train takes 7h 36m. The train service runs several times per day from Frankfurt South Station to Prague. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 4 hours between Frankfurt South Station and Prague. The earliest departure is at 4:33 AM at night, and the last departure from Frankfurt South Station is at 10:05 PM which arrives into Prague at 10:21 AM. All services require a transfer at Frankfurt and take an average of 8h 41m. The schedules shown below are for the next available departures.



7h 38m • 3 changes



7h 38m • 3 changes



7h 38m • 3 changes



7h 39m • 3 changes



7h 48m • 3 changes



7h 36m • 3 changes



7h 38m • 3 changes



7h 38m • 3 changes



7h 48m • 3 changes



7h 36m • 3 changes



7h 38m • 3 changes



7h 38m • 3 changes



7h 48m • 3 changes



7h 36m • 3 changes



7h 38m • 3 changes



7h 38m • 3 changes



7h 48m • 3 changes



7h 36m • 3 changes



7h 38m • 3 changes



7h 38m • 3 changes
Want to know about travelling from Frankfurt South Station to Prague? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Frankfurt South Station to Prague. However, there are services departing from Frankfurt South Station station and arriving at Prague station via Nürnberg Hbf. The journey, including transfers, takes approximately 8h 41m.
Frankfurt South Station to Prague train services, operated by Deutsche Bahn Regio (DB Regional), depart from Frankfurt station.
Frankfurt South Station to Prague train services, operated by Deutsche Bahn Regio (DB Regional), arrive at Praha Hlavni Nadrazi station.
Book your Frankfurt South Station to Prague train tickets online with Deutsche Bahn Regio (DB Regional), Deutsche Bahn Intercity (DB IC) and Die Länderbahn.
The distance between Frankfurt South Station and Prague is 409 km. The road distance is 569 km.
You can take a train from Frankfurt (Main) Süd to Praha Hlavni Nadrazi via Frankfurt, Nürnberg Hbf, and Schwandorf in around 8h 54m.