The average train between Frankfurt am Main and Iseo takes 15h 4m and the fastest train takes 10h 18m. The train service runs several times per day from Frankfurt am Main to Iseo. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 5 times a day between Frankfurt am Main and Iseo. The earliest departure is at 2:45 AM at night, and the last departure from Frankfurt am Main is at 10:20 PM which arrives into Iseo at 2:23 PM. All services require a transfer at Basel SBB and take an average of 15h 4m. The schedules shown below are for the next available departures.




10h 34m • 4 changes




11h 37m • 4 changes
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19h 34m • 4 changes
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16h 34m • 4 changes




10h 34m • 4 changes




11h 37m • 4 changes
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19h 34m • 4 changes
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16h 34m • 4 changes




10h 38m • 4 changes
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19h 34m • 4 changes
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16h 34m • 4 changes
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13h 4m • 4 changes




10h 38m • 4 changes




11h 37m • 4 changes
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19h 34m • 4 changes
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17h 38m • 4 changes




10h 18m • 4 changes




11h 36m • 4 changes
Arrives next day




19h 34m • 4 changes
Arrives next day




17h 38m • 4 changes




10h 18m • 4 changes




11h 36m • 4 changes
Arrives next day




19h 34m • 4 changes
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17h 38m • 4 changes
Want to know about travelling from Frankfurt am Main to Iseo? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Frankfurt am Main to Iseo. However, there are services departing from Frankfurt am Main station and arriving at Iseo station via Basel SBB. The journey, including transfers, takes approximately 15h 4m.
Frankfurt am Main to Iseo train services, operated by Deutsche Bahn Intercity (DB IC), depart from Frankfurt station.
Frankfurt am Main to Iseo train services, operated by Deutsche Bahn Intercity (DB IC), arrive at Brescia station.
Book your Frankfurt am Main to Iseo train tickets online with Deutsche Bahn Intercity (DB IC), Swiss Federal Railways (SBB CFF FFS) and 3 other operators.
The distance between Frankfurt am Main and Iseo is 505.8 km. The road distance is 768 km.
You can take a train from Frankfurt to Iseo via Basel SBB, Lugano, Milano Centrale, and Brescia in around 11h 1m.