The average train between Frankfurt am Main and Mendrisio takes 8h 23m and the fastest train takes 6h 21m. The train service runs several times per day from Frankfurt am Main to Mendrisio. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 4 hours between Frankfurt am Main and Mendrisio. The earliest departure is at 2:45 AM at night, and the last departure from Frankfurt am Main is at 10:20 PM which arrives into Mendrisio at 8:18 AM. All services require a transfer at Basel SBB and take an average of 8h 23m. The schedules shown below are for the next available departures.


7h 28m • 2 changes


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7h 37m • 2 changes


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7h 37m • 2 changes


7h 33m • 2 changes


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Arrives next day


7h 37m • 2 changes
Want to know about travelling from Frankfurt am Main to Mendrisio? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Frankfurt am Main to Mendrisio. However, there are services departing from Frankfurt am Main station and arriving at Mendrisio station via Basel SBB. The journey, including transfers, takes approximately 8h 23m.
Frankfurt am Main to Mendrisio train services, operated by Deutsche Bahn Intercity (DB IC), depart from Frankfurt station.
Frankfurt am Main to Mendrisio train services, operated by Deutsche Bahn Intercity (DB IC), arrive at Lugano station.
Book your Frankfurt am Main to Mendrisio train tickets online with Deutsche Bahn Intercity (DB IC) and Swiss Federal Railways (SBB CFF FFS).
The distance between Frankfurt am Main and Mendrisio is 472.5 km. The road distance is 601 km.
You can take a train from Frankfurt to Mendrisio via Basel SBB and Lugano in around 7h 12m.