The average train between Frankfurt am Main and a&o Berlin Mitte takes 4h 24m and the fastest train takes 4h 4m. There is an hourly train service from Frankfurt am Main to a&o Berlin Mitte. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Frankfurt am Main and a&o Berlin Mitte. The earliest departure is at 3:31 AM at night, and the last departure from Frankfurt am Main is at 9:15 PM which arrives into a&o Berlin Mitte at 3:27 AM. All services require a transfer at Berlin Hbf and take an average of 4h 24m. The schedules shown below are for the next available departures.

4h 29m • 1 change

4h 12m • 1 change

4h 29m • 1 change

4h 4m • 1 change

4h 48m • 1 change

4h 29m • 1 change

4h 4m • 1 change

4h 31m • 1 change

4h 48m • 1 change

4h 29m • 1 change

4h 4m • 1 change

4h 31m • 1 change
Want to know about travelling from Frankfurt am Main to a&o Berlin Mitte? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Frankfurt am Main to a&o Berlin Mitte. However, there are services departing from Frankfurt am Main station and arriving at a&o Berlin Mitte station via Berlin Hbf. The journey, including transfers, takes approximately 4h 24m.
Frankfurt am Main to a&o Berlin Mitte train services, operated by Deutsche Bahn Intercity (DB IC), depart from Frankfurt station.
Frankfurt am Main to a&o Berlin Mitte train services, operated by Deutsche Bahn Intercity (DB IC), arrive at Berlin Hbf station.
The distance between Frankfurt am Main and a&o Berlin Mitte is 423.4 km. The road distance is 516 km.
Deutsche Bahn Intercity (DB IC) operates a train from Frankfurt to Berlin Hbf hourly. Tickets cost €90–410 and the journey takes 4h 2m.