The average train between Frosinone and Brindisi takes 10h 35m and the fastest train takes 6h 49m. The train service runs several times per day from Frosinone to Brindisi. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 3 times a day between Frosinone and Brindisi. The earliest departure is at 8:35 AM in the morning, and the last departure from Frosinone is at 7:11 PM which arrives into Brindisi at 1:54 PM. All services require a transfer, and take on average 10h 35m. The schedules shown below are for the next available departures.

6h 53m • 1 change
6h 49m • 1 changeArrives next day

18h 43m • 1 change
6h 53m • 1 change
6h 49m • 1 changeArrives next day

18h 43m • 1 change
6h 53m • 1 change
6h 49m • 1 changeArrives next day

18h 43m • 1 change
6h 53m • 1 change
6h 49m • 1 changeArrives next day

18h 43m • 1 changeWant to know about travelling from Frosinone to Brindisi? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Frosinone to Brindisi. However, there are services departing from Frosinone station and arriving at Brindisi station via Caserta. The journey, including transfers, takes approximately 10h 35m.
Frosinone to Brindisi train services, operated by Trenitalia, depart from Frosinone station.
Frosinone to Brindisi train services, operated by Trenitalia, arrive at Brindisi station.
Book your Frosinone to Brindisi train tickets online with Trenitalia, Trenitalia Frecce and Trenitalia Intercity.
The distance between Frosinone and Brindisi is 400.7 km. The road distance is 521 km.
You can take a train from Frosinone to Brindisi via Caserta in around 6h 51m.