The average train between Genoa and Brindisi takes 13h 26m and the fastest train takes 10h 51m. The train service runs several times per day from Genoa to Brindisi. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 3 times a day between Genoa and Brindisi. The earliest departure is at 5:14 AM in the morning, and the last departure from Genoa is at 6:42 PM which arrives into Brindisi at 1:57 PM. All services require a transfer, and take on average 13h 26m. The schedules shown below are for the next available departures.

11h 19m • 1 change

11h 8m • 1 change
Arrives next day

19h 15m • 1 change

10h 51m • 1 change

11h 19m • 1 change

11h 8m • 1 change
Arrives next day

19h 15m • 1 change

10h 51m • 1 change

11h 19m • 1 change

11h 8m • 1 change
Arrives next day

19h 15m • 1 change

13h 23m • 1 change

11h 8m • 1 change
Arrives next day

19h 15m • 1 change

13h 23m • 1 change

11h 8m • 1 change
Arrives next day

19h 15m • 1 change
Want to know about travelling from Genoa to Brindisi? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Genoa to Brindisi. However, there are services departing from Genoa station and arriving at Brindisi station via Roma Termini. The journey, including transfers, takes approximately 13h 26m.
Genoa to Brindisi train services, operated by Trenitalia Intercity, depart from Genova Brignole station.
Genoa to Brindisi train services, operated by Trenitalia Intercity, arrive at Brindisi station.
Book your Genoa to Brindisi train tickets online with Trenitalia Intercity and Trenitalia Frecce.
The distance between Genoa and Brindisi is 847.3 km. The road distance is 1,078 km.
You can take a train from Genova Brignole to Brindisi via Roma Termini in around 11h 14m.