The average train between Genoa and Domodossola takes 4h 36m and the fastest train takes 3h 23m. The train service runs several times per day from Genoa to Domodossola. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 4 hours between Genoa and Domodossola. The earliest departure is at 5:44 AM in the morning, and the last departure from Genoa is at 9:44 PM which arrives into Domodossola at 8:43 AM. All services require a transfer, and take on average 4h 36m. The schedules shown below are for the next available departures.

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3h 24m • 1 changeWant to know about travelling from Genoa to Domodossola? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Genoa to Domodossola. However, there are services departing from Genova P.Za Principe station and arriving at Domodossola station via Milano Centrale station. The journey, including transfers, takes approximately 4h 36m.
Genoa to Domodossola train services, operated by Trenitalia Intercity, depart from Genova P.Za Principe station.
Genoa to Domodossola train services, operated by Trenitalia EuroCity, arrive at Domodossola station.
Book your Genoa to Domodossola train tickets online with Omio.
The distance between Genoa and Domodossola is 197 km. The road distance is 246 km.
You can take a train from Genova P.Za Principe to Domodossola via Milano Centrale in around 4h 15m.