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Greenville Station to St. Louis trains

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Trip Overview

The train between Greenville Station and St. Louis takes 42h 2m. The train runs, on average, 2 times per week from Greenville Station to St. Louis. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

42h 2m
Duration
1,453 mi
Distance
$920
Average price
Twice a week
Frequency

Greenville Station to St. Louis train times

Trains run twice a week between Greenville Station and St. Louis. The service departs Greenville Station at 2:23 AM at night, which arrives into St. Louis at 19:25:00. All services require a transfer at Charlottesville and take an average of 42h 2m. The schedules shown below are for the next available departures.

Departing Sunday, November 8, 2026

  •  → 

    Arrives next day

    AmtrakAmtrakAmtrak42h 2m • 2 changes

Departing Wednesday, November 11, 2026

  •  → 

    Arrives next day

    AmtrakAmtrakAmtrak42h 2m • 2 changes

Frequently asked questions

Want to know about travelling from Greenville Station to St. Louis? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Greenville Station to St. Louis.ExpandLaunch map view
  • Distance: 1,453.3 mi
  • Duration: 42h 2m

What companies run services between Greenville Station, SC, USA and St. Louis, MO, USA?

You can take a train from Greenville Amtrak Station to St. Louis via Charlottesville and Chicago Union Station in around 36h 10m.

Operators