The average train between Grenoble and Domodossola takes 9h 18m and the fastest train takes 6h 13m. The train service runs several times per day from Grenoble to Domodossola. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 3 times a day between Grenoble and Domodossola. The earliest departure is at 7:57 AM in the morning, and the last departure from Grenoble is at 5:58 PM which arrives into Domodossola at 8:10 AM. All services require a transfer, and take on average 9h 18m. The schedules shown below are for the next available departures.

8h 13m • 1 change
6h 13m • 1 changeArrives next day

14h 12m • 1 change
8h 13m • 1 change
6h 13m • 1 changeArrives next day

14h 12m • 1 change
8h 13m • 1 change
6h 13m • 1 changeArrives next day

14h 12m • 1 change
8h 13m • 1 change
6h 13m • 1 changeArrives next day

14h 12m • 1 changeWant to know about travelling from Grenoble to Domodossola? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Grenoble to Domodossola. However, there are services departing from Grenoble station and arriving at Domodossola station via Geneve. The journey, including transfers, takes approximately 9h 18m.
Grenoble to Domodossola train services, operated by Société Nationale des Chemins de fer Français (SNCF), depart from Grenoble station.
Grenoble to Domodossola train services, operated by Société Nationale des Chemins de fer Français (SNCF), arrive at Domodossola station.
Book your Grenoble to Domodossola train tickets online with Société Nationale des Chemins de fer Français (SNCF) and Swiss Federal Railways (SBB CFF FFS).
The distance between Grenoble and Domodossola is 225.9 km. The road distance is 412 km.
You can take a train from Grenoble to Domodossola via Genève in around 5h 56m.