The average train between Grenoble and La Défense takes 3h 19m and the fastest train takes 3h 17m. The train service runs several times per day from Grenoble to La Défense. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 5 times a day between Grenoble and La Défense. The earliest departure is at 5:46 AM in the morning, and the last departure from Grenoble is at 8:47 PM which arrives into La Défense at 12:13 AM. All services require a transfer, and take on average 3h 19m. The schedules shown below are for the next available departures.

3h 19m • 1 change

3h 20m • 1 change

3h 17m • 1 change

3h 17m • 1 change

3h 24m • 1 change

3h 18m • 1 change

3h 19m • 1 change

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3h 18m • 1 change

3h 17m • 1 change

3h 19m • 1 change

3h 17m • 1 change

3h 18m • 1 change

3h 20m • 1 change

3h 20m • 1 change

3h 19m • 1 change

3h 20m • 1 change

3h 20m • 1 change

3h 19m • 1 change

3h 22m • 1 change

3h 20m • 1 change

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3h 19m • 1 change

3h 22m • 1 change

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3h 20m • 1 change

3h 19m • 1 change

3h 22m • 1 change
Want to know about travelling from Grenoble to La Défense? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Grenoble to La Défense. However, there are services departing from Grenoble station and arriving at La Défense station via Paris Gare De Lyon. The journey, including transfers, takes approximately 3h 19m.
Grenoble to La Défense train services, operated by TGV inOui, depart from Grenoble station.
Grenoble to La Défense train services, operated by TGV inOui, arrive at Paris Gare De Lyon station.
The distance between Grenoble and La Défense is 489.7 km. The road distance is 565 km.
TGV inOui operates a train from Grenoble to Paris Gare De Lyon hourly. Tickets cost €110–180 and the journey takes 3h 1m.