The average train between Grenoble and Lille takes 5h 36m and the fastest train takes 4h 36m. The train service runs several times per day from Grenoble to Lille. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 4 hours between Grenoble and Lille. The earliest departure is at 6:21 AM in the morning, and the last departure from Grenoble is at 9:21 PM which arrives into Lille at 8:58 AM. All services require a transfer, and take on average 5h 36m. The schedules shown below are for the next available departures.

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4h 37m • 1 changeWant to know about travelling from Grenoble to Lille? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Grenoble to Lille. However, there are services departing from Grenoble station and arriving at Lille Europe station via Lyon Part Dieu station. The journey, including transfers, takes approximately 5h 36m.
Grenoble to Lille train services, operated by Société Nationale des Chemins de fer Français (SNCF), depart from Grenoble station.
Grenoble to Lille train services, operated by TGV inOui, arrive at Lille Europe station.
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The distance between Grenoble and Lille is 637.9 km. The road distance is 767 km.
You can take a train from Grenoble to Lille Europe via Lyon Part Dieu in around 4h 57m.