The average train between Heilbronn and Brindisi takes 22h 43m and the fastest train takes 17h 7m. The train service runs several times per day from Heilbronn to Brindisi. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 3 times a day between Heilbronn and Brindisi. The earliest departure is at 4:19 AM at night, and the last departure from Heilbronn is at 11:34 PM which arrives into Brindisi at 8:34 PM. All services require a transfer at Karlsruhe Hauptbahnhof and take an average of 22h 43m. The schedules shown below are for the next available departures.
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26h 31m • 5 changes
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24h 50m • 5 changes
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21h • 5 changes





17h 7m • 5 changes
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26h 31m • 5 changes
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24h 50m • 5 changes
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21h • 5 changes





17h 7m • 5 changes
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26h 31m • 5 changes
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25h 50m • 5 changes
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22h 58m • 5 changes
Want to know about travelling from Heilbronn to Brindisi? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Heilbronn to Brindisi. However, there are services departing from Heilbronn station and arriving at Brindisi station via Karlsruhe Hauptbahnhof. The journey, including transfers, takes approximately 22h 43m.
Heilbronn to Brindisi train services, operated by Deutsche Bahn Regio (DB Regional), depart from Heilbronn Hauptbahnhof station.
Heilbronn to Brindisi train services, operated by Deutsche Bahn Regio (DB Regional), arrive at Brindisi station.
Book your Heilbronn to Brindisi train tickets online with Deutsche Bahn Regio (DB Regional), Deutsche Bahn Intercity (DB IC) and 4 other operators.
The distance between Heilbronn and Brindisi is 1,167.3 km. The road distance is 1,562 km.
You can take a train from Heilbronn Hauptbahnhof to Brindisi via Karlsruhe Hauptbahnhof, Basel SBB, Lugano, Milano Centrale, and Reggio Emilia Av in around 18h 24m.