The average train between Iseo and Rome takes 5h 52m and the fastest train takes 4h 49m. There is a train service every few hours from Iseo to Rome. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Iseo and Rome. The earliest departure is at 5:36 AM in the morning, and the last departure from Iseo is at 8:36 PM which arrives into Rome at 9:19 AM. All services require a transfer at Brescia and take an average of 5h 52m. The schedules shown below are for the next available departures.


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5h 43m • 2 changesWant to know about travelling from Iseo to Rome? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Iseo to Rome. However, there are services departing from Iseo station and arriving at Rome station via Milano Centrale. The journey, including transfers, takes approximately 5h 52m.
Iseo to Rome train services, operated by Trenord, depart from Brescia station.
Iseo to Rome train services, operated by Trenord, arrive at Roma Termini station.
Book your Iseo to Rome train tickets online with Trenord, Trenitalia Frecce and ItaloTreno.
The distance between Iseo and Rome is 461.8 km. The road distance is 689 km.
You can take a train from Iseo to Roma Termini via Brescia and Milano Centrale in around 5h 17m.