The average train between Isernia and Avezzano takes 6h 34m and the fastest train takes 3h 27m. The train service runs several times per day from Isernia to Avezzano. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 3 times a day between Isernia and Avezzano. The earliest departure is at 8:38 AM in the morning, and the last departure from Isernia is at 8:35 PM which arrives into Avezzano at 7:54 AM. All services require a transfer, and take on average 6h 34m. The schedules shown below are for the next available departures.

6h 36m • 1 change

3h 36m • 1 change
Arrives next day

11h 19m • 1 change

6h 36m • 1 change

3h 36m • 1 change
Arrives next day

11h 19m • 1 change

6h 36m • 1 change

3h 36m • 1 change
Arrives next day

11h 19m • 1 change
Want to know about travelling from Isernia to Avezzano? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Isernia to Avezzano. However, there are services departing from Isernia station and arriving at Avezzano station via Cassino. The journey, including transfers, takes approximately 6h 34m.
Isernia to Avezzano train services, operated by Trenitalia, depart from Isernia station.
Isernia to Avezzano train services, operated by Trenitalia, arrive at Avezzano station.
Book your Isernia to Avezzano train tickets online with Trenitalia.
The distance between Isernia and Avezzano is 82.4 km. The road distance is 147 km.
You can take a train from Isernia to Avezzano via Cassino in around 4h 12m.