The average train between Isernia and Brussels takes 20h 24m and the fastest train takes 14h 38m. The train service runs several times per day from Isernia to Brussels. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 3 times a day between Isernia and Brussels. The earliest departure is at 6:35 AM in the morning, and the last departure from Isernia is at 3:03 PM which arrives into Brussels at 3:17 PM. All services require a transfer at Roma Termini and take an average of 20h 24m. The schedules shown below are for the next available departures.





14h 59m • 5 changes
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23h 9m • 5 changes
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24h 45m • 5 changes





14h 59m • 5 changes
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23h 9m • 5 changes
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24h 45m • 5 changes





14h 59m • 5 changes
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23h 9m • 5 changes
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24h 45m • 5 changes





14h 59m • 5 changes
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22h 56m • 5 changes
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24h 45m • 5 changes





14h 59m • 5 changes
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23h 56m • 5 changes
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24h 31m • 5 changes
Want to know about travelling from Isernia to Brussels? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Isernia to Brussels. However, there are services departing from Isernia station and arriving at Brussels station via Roma Termini. The journey, including transfers, takes approximately 20h 24m.
Isernia to Brussels train services, operated by Trenitalia, depart from Isernia station.
Isernia to Brussels train services, operated by Trenitalia, arrive at Brussel-Zuid / Bruxelles-Midi station.
Book your Isernia to Brussels train tickets online with Trenitalia, ItaloTreno and 3 other operators.
The distance between Isernia and Brussels is 1,277.2 km. The road distance is 1,935 km.
You can take a train from Isernia to Brussel-Zuid / Bruxelles-Midi via Roma Termini, Milano Centrale, Torino Porta Susa, Paris Gare de Lyon, and Paris Nord in around 15h 14m.