The average train between Isernia and Florence takes 5h 41m and the fastest train takes 3h 53m. The train service runs several times per day from Isernia to Florence. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 4 times a day between Isernia and Florence. The earliest departure is at 6:35 AM in the morning, and the last departure from Isernia is at 8:35 PM which arrives into Florence at 7:17 AM. All services require a transfer, and take on average 5h 41m. The schedules shown below are for the next available departures.

4h 42m • 1 change
3h 53m • 1 change
4h 14m • 1 changeArrives next day

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3h 53m • 1 change
4h 14m • 1 changeArrives next day

10h 42m • 1 change
4h 42m • 1 change
3h 53m • 1 change
4h 14m • 1 changeArrives next day

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4h 42m • 1 change
3h 53m • 1 change
4h 14m • 1 changeArrives next day

10h 42m • 1 changeWant to know about travelling from Isernia to Florence? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Isernia to Florence. However, there are services departing from Isernia station and arriving at Florence station via Roma Termini. The journey, including transfers, takes approximately 5h 41m.
Isernia to Florence train services, operated by Trenitalia, depart from Isernia station.
Isernia to Florence train services, operated by Trenitalia, arrive at Firenze Santa Maria Novella station.
Book your Isernia to Florence train tickets online with Trenitalia and ItaloTreno.
The distance between Isernia and Florence is 344.3 km. The road distance is 447 km.
You can take a train from Isernia to Firenze Santa Maria Novella via Roma Termini in around 4h 13m.