Isernia to Florence Trains

Isernia to Florence trains

Travel from

Search accommodation with Expedia

Trip Overview

The average train between Isernia and Florence takes 5h 21m and the fastest train takes 4h 6m. The train service runs several times per day from Isernia to Florence. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

5h 21m
Duration: 447 km
Distance: €61
Average price: 3 times a day
Frequency

Train (Trenitalia)

best

Take the train from Isernia to Roma Terminitrain Re
Take the train from Roma Termini to Firenze S.M.N.train Fr

4h 13m

€50–95

Isernia to Florence train times

Trains run 3 times a day between Isernia and Florence. The earliest departure is at 6:40 AM in the morning, and the last departure from Isernia is at 8:35 PM which arrives into Florence at 6:46 AM. All services require a transfer, and take on average 5h 21m. The schedules shown below are for the next available departures.

Departing Monday, October 26, 2026

6:40 AM → 10:46 AM
4h 6m • 1 change
8:38 AM → 12:46 PM
4h 8m • 1 change
3:03 PM → 7:27 PM
4h 24m • 1 change
6:00 PM → 10:58 PM
4h 58m • 1 change
Show more

Departing Tuesday, October 27, 2026

6:40 AM → 10:46 AM
4h 6m • 1 change
8:38 AM → 12:46 PM
4h 8m • 1 change
3:03 PM → 7:27 PM
4h 24m • 1 change
6:00 PM → 10:58 PM
4h 58m • 1 change
Show more

Departing Wednesday, October 28, 2026

6:40 AM → 10:46 AM
4h 6m • 1 change
8:38 AM → 12:46 PM
4h 8m • 1 change
3:03 PM → 7:27 PM
4h 24m • 1 change
6:00 PM → 10:58 PM
4h 58m • 1 change
Show more

Departing Thursday, October 29, 2026

6:40 AM → 10:46 AM
4h 6m • 1 change
8:38 AM → 12:46 PM
4h 8m • 1 change
3:03 PM → 7:27 PM
4h 24m • 1 change
6:00 PM → 10:58 PM
4h 58m • 1 change
Show more

Departing Friday, October 30, 2026

6:40 AM → 10:46 AM
4h 6m • 1 change
8:38 AM → 12:46 PM
4h 8m • 1 change
3:03 PM → 7:27 PM
4h 24m • 1 change
6:00 PM → 10:58 PM
4h 58m • 1 change

Frequently asked questions

Want to know about travelling from Isernia to Florence? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.