The average train between Isernia and Pisa takes 7h 36m and the fastest train takes 5h 13m. The train service runs several times per day from Isernia to Pisa. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 4 times a day between Isernia and Pisa. The earliest departure is at 6:40 AM in the morning, and the last departure from Isernia is at 8:35 PM which arrives into Pisa at 8:45 AM. All services require a transfer, and take on average 7h 36m. The schedules shown below are for the next available departures.

6h 19m • 1 change
6h 11m • 1 change
6h 1m • 1 change
5h 13m • 1 changeWant to know about travelling from Isernia to Pisa? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Isernia to Pisa. However, there are services departing from Isernia station and arriving at Pisa Centrale station via Roma Termini station. The journey, including transfers, takes approximately 7h 36m.
Isernia to Pisa train services, operated by Trenitalia, depart from Isernia station.
Isernia to Pisa train services, operated by Trenitalia Frecce, arrive at Pisa Centrale station.
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The distance between Isernia and Pisa is 391.5 km. The road distance is 507 km.
You can take a train from Isernia to Pisa Centrale via Roma Termini in around 5h 39m.