The average train between Isernia and Sicily takes 14h 25m and the fastest train takes 12h 21m. There is at least one train per day from Isernia to Sicily. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run once daily between Isernia and Sicily. The earliest departure is at 7:08 AM in the morning, and the last departure from Isernia is at 7:01 PM which arrives into Sicily at 8:25 PM. All services require a transfer at Napoli Centrale and take an average of 14h 25m. The schedules shown below are for the next available departures.
Want to know about travelling from Isernia to Sicily? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Isernia to Sicily. However, there are services departing from Isernia station and arriving at Sicily station via Napoli Centrale. The journey, including transfers, takes approximately 14h 25m.
Isernia to Sicily train services, operated by Trenitalia, depart from Isernia station.
Isernia to Sicily train services, operated by Trenitalia, arrive at Palermo Centrale station.
Book your Isernia to Sicily train tickets online with Trenitalia and Trenitalia Intercity.
The distance between Isernia and Sicily is 445.7 km. The road distance is 788 km.
You can take a train from Isernia to Palermo Notarbartolo via Napoli Centrale and Palermo Centrale in around 12h 54m.
