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Isernia to Siena trains

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Trip Overview

The average train between Isernia and Siena takes 8h 44m and the fastest train takes 5h 58m. The train service runs several times per day from Isernia to Siena. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

8h 44m
Duration
540 km
Distance
€74
Average price
3 times a day
Frequency

Train (Trenitalia)

best
  1. Take the train from Isernia to Roma Terminitrain train Re
  2. Take the train from Roma Termini to Firenze S.M.N.train train Fr
  3. Take the train from Firenze S.M.N. to Sienatrain train Re
6h 3m
€60–111

Isernia to Siena train times

Trains run 3 times a day between Isernia and Siena. The earliest departure is at 6:40 AM in the morning, and the last departure from Isernia is at 8:35 PM which arrives into Siena at 9:38 AM. All services require a transfer at Roma Termini and take an average of 8h 44m. The schedules shown below are for the next available departures.

Departing Monday, October 12, 2026

  •  → 

    Arrives next day

    TrenitaliaTrenitalia FrecceTrenitalia13h 3m • 2 changes

Departing Tuesday, October 13, 2026

  •  → 

    TrenitaliaTrenitalia FrecceTrenitalia5h 58m • 2 changes

  •  → 

    TrenitaliaTrenitalia FrecceTrenitalia6h 2m • 2 changes

  •  → 

    TrenitaliaTrenitalia FrecceTrenitalia6h 36m • 2 changes

  •  → 

    Arrives next day

    TrenitaliaTrenitalia FrecceTrenitalia13h 55m • 2 changes
  • Show more

Departing Wednesday, October 14, 2026

  •  → 

    TrenitaliaTrenitalia FrecceTrenitalia5h 58m • 2 changes

  •  → 

    TrenitaliaTrenitalia FrecceTrenitalia6h 2m • 2 changes

  •  → 

    TrenitaliaTrenitalia FrecceTrenitalia6h 36m • 2 changes

  •  → 

    Arrives next day

    TrenitaliaTrenitalia FrecceTrenitalia13h 55m • 2 changes
  • Show more

Departing Thursday, October 15, 2026

  •  → 

    TrenitaliaTrenitalia FrecceTrenitalia5h 58m • 2 changes

  •  → 

    TrenitaliaTrenitalia FrecceTrenitalia6h 2m • 2 changes

  •  → 

    TrenitaliaTrenitalia FrecceTrenitalia6h 36m • 2 changes

  •  → 

    Arrives next day

    TrenitaliaTrenitalia FrecceTrenitalia13h 55m • 2 changes
  • Show more

Departing Friday, October 16, 2026

  •  → 

    TrenitaliaTrenitalia FrecceTrenitalia5h 58m • 2 changes

  •  → 

    TrenitaliaTrenitalia FrecceTrenitalia6h 2m • 2 changes

  •  → 

    TrenitaliaTrenitalia FrecceTrenitalia6h 36m • 2 changes

Frequently asked questions

Want to know about travelling from Isernia to Siena? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Isernia to Siena.ExpandLaunch map view
  • Distance: 539.9 km
  • Duration: 8h 44m

What companies run services between Isernia, Italy and Siena, Italy?

You can take a train from Isernia to Siena via Roma Termini and Firenze S.M.N. in around 6h 3m.

Operators