The average train between Isleworth and Holyhead takes 5h 2m and the fastest train takes 4h 40m. The train service runs several times per day from Isleworth to Holyhead. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 5 times a day between Isleworth and Holyhead. The earliest departure is at 7:02 AM in the morning, and the last departure from Isleworth is at 6:50 PM which arrives into Holyhead at 11:53 PM. All services require a transfer at Vauxhall and take an average of 5h 2m. The schedules shown below are for the next available departures.


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5h 3m • 2 changesWant to know about travelling from Isleworth to Holyhead? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Isleworth to Holyhead. However, there are services departing from London Euston station and arriving at Holyhead station via Holyhead station. The journey, including transfers, takes approximately 5h 2m.
Isleworth to Holyhead train services, operated by Avanti West Coast, depart from London Euston station.
Isleworth to Holyhead train services, operated by Avanti West Coast, arrive at Holyhead station.
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The distance between Isleworth and Holyhead is 355.5 km. The road distance is 414 km.
Avanti West Coast operates a train from London Euston to Holyhead 5 times a day. Tickets cost £85–140 and the journey takes 3h 52m.