The average train between Istres and Lyon takes 4h 38m and the fastest train takes 2h 58m. The train service runs several times per day from Istres to Lyon. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 4 hours between Istres and Lyon. The earliest departure is at 8:16 AM in the morning, and the last departure from Istres is at 9:49 PM which arrives into Lyon at 8:20 AM. All services require a transfer at Miramas and take an average of 4h 38m. The schedules shown below are for the next available departures.


3h 12m • 2 changes


3h 37m • 2 changes


4h 4m • 2 changes


3h 35m • 2 changes


3h 12m • 2 changes


3h 37m • 2 changes


3h 12m • 2 changes


3h 35m • 2 changes


3h 12m • 2 changes


3h 37m • 2 changes


3h 12m • 2 changes


3h 35m • 2 changes


3h 37m • 2 changes


2h 58m • 2 changes


3h 35m • 2 changes


3h 10m • 2 changes


3h 37m • 2 changes


3h 3m • 2 changes


3h 35m • 2 changes


3h 10m • 2 changes


3h 12m • 2 changes


3h 37m • 2 changes


3h 12m • 2 changes


3h 35m • 2 changes
Want to know about travelling from Istres to Lyon? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Istres to Lyon. However, there are services departing from Istres station and arriving at Lyon station via Marseille Saint-Charles. The journey, including transfers, takes approximately 4h 38m.
Istres to Lyon train services, operated by Zou! Lignes Express Régionales, depart from Miramas station.
Istres to Lyon train services, operated by Zou! Lignes Express Régionales, arrive at Lyon Part Dieu station.
Book your Istres to Lyon train tickets online with Zou! Lignes Express Régionales, Société Nationale des Chemins de fer Français (SNCF) and TGV inOui.
The distance between Istres and Lyon is 248.8 km. The road distance is 383 km.
You can take a train from Istres to Lyon Part Dieu via Miramas, Marseille Saint-Charles, and Marseille St Charles in around 3h 26m.