The average train between Karlovy Vary and Frankfurt am Main takes 5h 33m and the fastest train takes 5h 15m. The train service runs several times per day from Karlovy Vary to Frankfurt am Main. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 5 times a day between Karlovy Vary and Frankfurt am Main. The earliest departure is at 5:50 AM in the morning, and the last departure from Karlovy Vary is at 6:08 PM which arrives into Frankfurt am Main at 12:03 AM. All services require a transfer at Cheb and take an average of 5h 33m. The schedules shown below are for the next available departures.


5h 40m • 2 changes


6h 2m • 2 changes


5h 15m • 2 changes


5h 15m • 2 changes


5h 15m • 2 changes


6h 2m • 2 changes


5h 15m • 2 changes


5h 15m • 2 changes


5h 15m • 2 changes


6h 2m • 2 changes


5h 15m • 2 changes


5h 15m • 2 changes


5h 15m • 2 changes


6h 2m • 2 changes


5h 15m • 2 changes


5h 15m • 2 changes
Want to know about travelling from Karlovy Vary to Frankfurt am Main? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Karlovy Vary to Frankfurt am Main. However, there are services departing from Karlovy Vary station and arriving at Frankfurt am Main station via Cheb. The journey, including transfers, takes approximately 5h 33m.
Karlovy Vary to Frankfurt am Main train services, operated by České dráhy (ČD), depart from Karlovy Vary station.
Karlovy Vary to Frankfurt am Main train services, operated by České dráhy (ČD), arrive at Frankfurt station.
Book your Karlovy Vary to Frankfurt am Main train tickets online with České dráhy (ČD) and Deutsche Bahn Intercity (DB IC).
The distance between Karlovy Vary and Frankfurt am Main is 298.4 km. The road distance is 425 km.
You can take a train from Karlovy Vary to Frankfurt via Cheb, Nuernberg Hbf, and Nürnberg Hbf in around 6h 2m.