The average train between Karlovy Vary and Lyon takes 21h 29m and the fastest train takes 15h 24m. The train service runs several times per day from Karlovy Vary to Lyon. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run twice daily between Karlovy Vary and Lyon. The earliest departure is at 5:50 AM in the morning, and the last departure from Karlovy Vary is at 6:08 PM which arrives into Lyon at 12:59 PM. All services require a transfer at Cheb and take an average of 21h 29m. The schedules shown below are for the next available departures.
Arrives next day




24h 37m • 4 changes
Arrives next day




18h 51m • 4 changes
Arrives next day




24h 37m • 4 changes
Arrives next day




18h 51m • 4 changes
Want to know about travelling from Karlovy Vary to Lyon? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Karlovy Vary to Lyon. However, there are services departing from Karlovy Vary station and arriving at Lyon station via Cheb. The journey, including transfers, takes approximately 21h 29m.
Karlovy Vary to Lyon train services, operated by České dráhy (ČD), depart from Karlovy Vary station.
Karlovy Vary to Lyon train services, operated by České dráhy (ČD), arrive at Lyon Part Dieu station.
Book your Karlovy Vary to Lyon train tickets online with České dráhy (ČD), Arverio Baden-Württemberg and 2 other operators.
The distance between Karlovy Vary and Lyon is 777.2 km. The road distance is 1,054 km.
You can take a train from Karlovy Vary to Lyon Part Dieu via Cheb, Nuernberg Hbf, Stuttgart Hbf, Hauptbahnhof, Strasbourg Bahnhof, and Strasbourg in around 13h 57m.