The average train between Karlsruhe Hbf and Brussels takes 5h 22m and the fastest train takes 4h 36m. The train service runs several times per day from Karlsruhe Hbf to Brussels. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 4 hours between Karlsruhe Hbf and Brussels. The earliest departure is at 1:24 AM at night, and the last departure from Karlsruhe Hbf is at 8:59 PM which arrives into Brussels at 8:35 AM. All services require a transfer, and take on average 5h 22m. The schedules shown below are for the next available departures.

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4h 36m • 1 changeWant to know about travelling from Karlsruhe Hbf to Brussels? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Karlsruhe Hbf to Brussels. However, there are services departing from Karlsruhe Hbf station and arriving at Brussels station via Köln Hbf. The journey, including transfers, takes approximately 5h 22m.
Karlsruhe Hbf to Brussels train services, operated by Deutsche Bahn Intercity (DB IC), depart from Karlsruhe Hauptbahnhof station.
Karlsruhe Hbf to Brussels train services, operated by Deutsche Bahn Intercity (DB IC), arrive at Bruxelles Midi station.
Book your Karlsruhe Hbf to Brussels train tickets online with Deutsche Bahn Intercity (DB IC) and Eurostar.
The distance between Karlsruhe Hbf and Brussels is 356 km. The road distance is 519 km.
You can take a train from Karlsruhe Hauptbahnhof to Bruxelles Midi via Köln Hbf in around 4h 47m.