The average train between Karlsruhe and Brno takes 11h 19m and the fastest train takes 10h 9m. The train service runs several times per day from Karlsruhe to Brno. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 5 times a day between Karlsruhe and Brno. The earliest departure is at 6:00 AM in the morning, and the last departure from Karlsruhe is at 2:06 PM which arrives into Brno at 6:41 AM. All services require a transfer at Stuttgart Hbf and take an average of 11h 19m. The schedules shown below are for the next available departures.



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10h 9m • 3 changesWant to know about travelling from Karlsruhe to Brno? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Karlsruhe to Brno. However, there are services departing from Karlsruhe Hbf station and arriving at Brno Hlavni Nadrazi station via Stuttgart Hbf station, Salzburg Hbf station and Wien Hbf station. The journey, including transfers, takes approximately 11h 19m.
Karlsruhe to Brno train services, operated by Arverio Baden-Württemberg, depart from Karlsruhe Hbf station.
Karlsruhe to Brno train services, operated by Railjet, arrive at Brno Hlavni Nadrazi station.
Book your Karlsruhe to Brno train tickets online with Omio.
The distance between Karlsruhe and Brno is 597.3 km. The road distance is 725 km.
You can take a train from Karlsruhe Hbf to Brno Hlavni Nadrazi via Stuttgart Hbf, Salzburg Hbf, and Wien Hbf in around 10h 57m.