The average train between Karlsruhe and Lugano takes 5h 9m and the fastest train takes 4h 57m. The train service runs several times per day from Karlsruhe to Lugano. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 4 hours between Karlsruhe and Lugano. The earliest departure is at 4:03 AM at night, and the last departure from Karlsruhe is at 7:01 PM which arrives into Lugano at 11:58 PM. All services require a transfer, and take on average 5h 9m. The schedules shown below are for the next available departures.

5h 55m • 1 change

4h 57m • 1 change

4h 57m • 1 change

4h 57m • 1 change

5h 54m • 1 change

4h 57m • 1 change

4h 57m • 1 change

4h 57m • 1 change

5h 55m • 1 change

4h 57m • 1 change

4h 57m • 1 change

4h 57m • 1 change

5h 55m • 1 change

4h 57m • 1 change

4h 57m • 1 change

4h 57m • 1 change

5h 54m • 1 change

4h 57m • 1 change

4h 57m • 1 change

5h 57m • 1 change
Want to know about travelling from Karlsruhe to Lugano? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Karlsruhe to Lugano. However, there are services departing from Karlsruhe station and arriving at Lugano station via Basel SBB. The journey, including transfers, takes approximately 5h 9m.
Karlsruhe to Lugano train services, operated by Nederlandse Spoorwegen (NS), depart from Karlsruhe Hauptbahnhof station.
Karlsruhe to Lugano train services, operated by Nederlandse Spoorwegen (NS), arrive at Lugano station.
Book your Karlsruhe to Lugano train tickets online with Nederlandse Spoorwegen (NS), Swiss Federal Railways (SBB CFF FFS) and 2 other operators.
The distance between Karlsruhe and Lugano is 336.1 km. The road distance is 446 km.
You can take a train from Karlsruhe Hauptbahnhof to Lugano via Basel SBB in around 5h 41m.