The average train between Karlsruhe and Neuss takes 3h 23m and the fastest train takes 3h 7m. The train service runs several times per day from Karlsruhe to Neuss. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 4 hours between Karlsruhe and Neuss. The earliest departure is at 1:24 AM at night, and the last departure from Karlsruhe is at 8:59 PM which arrives into Neuss at 12:06 AM. All services require a transfer, and take on average 3h 23m. The schedules shown below are for the next available departures.

3h 7m • 1 change

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5h 9m • 1 change

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5h 9m • 1 change

3h 7m • 1 change

3h 7m • 1 change

3h 7m • 1 change

5h 9m • 1 change

3h 7m • 1 change

3h 7m • 1 change

3h 7m • 1 change

5h 9m • 1 change

3h 7m • 1 change

3h 7m • 1 change

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3h 7m • 1 change
Want to know about travelling from Karlsruhe to Neuss? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Karlsruhe to Neuss. However, there are services departing from Karlsruhe station and arriving at Neuss station via Köln Hbf. The journey, including transfers, takes approximately 3h 23m.
Karlsruhe to Neuss train services, operated by Deutsche Bahn Intercity (DB IC), depart from Karlsruhe Hauptbahnhof station.
Karlsruhe to Neuss train services, operated by Deutsche Bahn Intercity (DB IC), arrive at Köln Hbf station.
Book your Karlsruhe to Neuss train tickets online with Deutsche Bahn Intercity (DB IC) and National Express.
The distance between Karlsruhe and Neuss is 272.5 km. The road distance is 336 km.
Deutsche Bahn Intercity (DB IC) operates a train from Karlsruhe Hauptbahnhof to Köln Hbf every 3 hours. Tickets cost €55–230 and the journey takes 2h 6m.