The average train between Karlsruhe and Prague takes 10h 2m and the fastest train takes 8h 59m. There is at least one train per day from Karlsruhe to Prague. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run once daily between Karlsruhe and Prague. The earliest departure is at 7:06 AM in the morning, and the last departure from Karlsruhe is at 11:12 PM which arrives into Prague at 12:21 PM. All services require a transfer at Stuttgart Hbf and take an average of 10h 2m. The schedules shown below are for the next available departures.


9h 15m • 2 changes


9h 15m • 2 changes


8h 59m • 2 changes


9h 16m • 2 changes
Want to know about travelling from Karlsruhe to Prague? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Karlsruhe to Prague. However, there are services departing from Karlsruhe station and arriving at Prague station via Stuttgart Hbf. The journey, including transfers, takes approximately 10h 2m.
Karlsruhe to Prague train services, operated by Deutsche Bahn Intercity (DB IC), depart from Karlsruhe Hbf station.
Karlsruhe to Prague train services, operated by Deutsche Bahn Intercity (DB IC), arrive at Praha Hlavni Nadrazi station.
Book your Karlsruhe to Prague train tickets online with Deutsche Bahn Intercity (DB IC), Die Länderbahn and 2 other operators.
The distance between Karlsruhe and Prague is 450.2 km. The road distance is 741 km.
You can take a train from Karlsruhe Hbf to Praha Hlavni Nadrazi via Stuttgart Hbf, Hauptbahnhof, and Muenchen Hbf in around 9h 22m.