The average train between Karlsruhe and Prague takes 10h 27m and the fastest train takes 9h 15m. The train service runs several times per day from Karlsruhe to Prague. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 5 times a day between Karlsruhe and Prague. The earliest departure is at 7:06 AM in the morning, and the last departure from Karlsruhe is at 7:06 PM which arrives into Prague at 10:21 AM. All services require a transfer at Nürnberg Hbf and take an average of 10h 27m. The schedules shown below are for the next available departures.


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9h 16m • 2 changesWant to know about travelling from Karlsruhe to Prague? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Karlsruhe to Prague. However, there are services departing from Karlsruhe station and arriving at Prague station via Nürnberg Hbf. The journey, including transfers, takes approximately 10h 27m.
Karlsruhe to Prague train services, operated by Deutsche Bahn Intercity (DB IC), depart from Karlsruhe Hauptbahnhof station.
Karlsruhe to Prague train services, operated by Deutsche Bahn Intercity (DB IC), arrive at Praha Hlavni Nadrazi station.
Book your Karlsruhe to Prague train tickets online with Deutsche Bahn Intercity (DB IC), Deutsche Bahn Regio (DB Regional) and Die Länderbahn.
The distance between Karlsruhe and Prague is 450.2 km. The road distance is 623 km.
You can take a train from Karlsruhe Hauptbahnhof to Praha Hlavni Nadrazi via Nürnberg Hbf, Nürnberg Hbf, and Schwandorf in around 9h 18m.