The average train between Karlstein am Main and Cologne takes 2h 20m and the fastest train takes 1h 47m. There is a train service every few hours from Karlstein am Main to Cologne. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Karlstein am Main and Cologne. The earliest departure is at 6:46 AM in the morning, and the last departure from Karlstein am Main is at 7:51 PM which arrives into Cologne at 10:14 PM. All services require a transfer, and take on average 2h 20m. The schedules shown below are for the next available departures.

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2h 21m • 1 changeWant to know about travelling from Karlstein am Main to Cologne? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Karlstein am Main to Cologne. However, there are services departing from Hanau Hauptbahnhof station and arriving at Köln Messe/Deutz Bf station via Köln Messe/Deutz Bf station. The journey, including transfers, takes approximately 2h 20m.
Karlstein am Main to Cologne train services, operated by Deutsche Bahn Intercity (DB IC), depart from Hanau Hauptbahnhof station.
Karlstein am Main to Cologne train services, operated by Deutsche Bahn Intercity (DB IC), arrive at Köln Messe/Deutz Bf station.
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The distance between Karlstein am Main and Cologne is 176.8 km. The road distance is 220 km.
Deutsche Bahn Intercity (DB IC) operates a train from Hanau Hauptbahnhof to Köln Messe/Deutz Bf hourly. Tickets cost €30–65 and the journey takes 1h 28m.