The average train between Kassel and Karlsruhe takes 3h 11m and the fastest train takes 2h 44m. There is a train service every few hours from Kassel to Karlsruhe. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Kassel and Karlsruhe. The earliest departure is at 6:00 AM in the morning, and the last departure from Kassel is at 8:39 PM which arrives into Karlsruhe at 11:23 PM. All services require a transfer, and take on average 3h 11m. The schedules shown below are for the next available departures.

3h 15m • 1 change

3h 8m • 1 change

4h 1m • 1 change

2h 44m • 1 change

3h 15m • 1 change

3h 8m • 1 change

4h 1m • 1 change

2h 44m • 1 change

3h 15m • 1 change

3h 8m • 1 change

4h 1m • 1 change

2h 44m • 1 change

3h 19m • 1 change

4h 1m • 1 change

3h • 1 change

3h • 1 change
Want to know about travelling from Kassel to Karlsruhe? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Kassel to Karlsruhe. However, there are services departing from Kassel station and arriving at Karlsruhe station via Karlsruhe Hauptbahnhof. The journey, including transfers, takes approximately 3h 11m.
Kassel to Karlsruhe train services, operated by Deutsche Bahn Regio (DB Regional), depart from Kassel Bahnhof Wilhelmshöhe station.
Kassel to Karlsruhe train services, operated by Deutsche Bahn Regio (DB Regional), arrive at Karlsruhe Hauptbahnhof station.
Book your Kassel to Karlsruhe train tickets online with Deutsche Bahn Regio (DB Regional), Deutsche Bahn Intercity (DB IC) and 3 other operators.
The distance between Kassel and Karlsruhe is 268.2 km. The road distance is 332 km.
Deutsche Bahn Intercity (DB IC) operates a train from Kassel Bahnhof Wilhelmshöhe to Karlsruhe Hauptbahnhof hourly. Tickets cost €60–260 and the journey takes 2h 35m.