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La Crosse to Buffalo trains

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Trip Overview

The train between La Crosse and Buffalo takes 24h 13m. The train runs, on average, 6 times per week from La Crosse to Buffalo. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

24h 13m
Duration
814 mi
Distance
$557
Average price
6 times a week
Frequency

La Crosse to Buffalo train times

Trains run 6 times a week between La Crosse and Buffalo. The service departs La Crosse at 2:17 PM in the afternoon, which arrives into Buffalo at 15:30:00. All services require a transfer at Chicago Union Station and take an average of 24h 13m. The schedules shown below are for the next available departures.

Departing Wednesday, November 4, 2026

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    Arrives next day

    AmtrakAmtrakVIA Rail24h 13m • 2 changes

Departing Thursday, November 5, 2026

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    Arrives next day

    AmtrakAmtrakVIA Rail24h 13m • 2 changes

Departing Friday, November 6, 2026

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    Arrives next day

    AmtrakAmtrakVIA Rail24h 13m • 2 changes

Departing Saturday, November 7, 2026

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    Arrives next day

    AmtrakAmtrakVIA Rail24h 13m • 2 changes

Departing Sunday, November 8, 2026

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    Arrives next day

    AmtrakAmtrakVIA Rail24h 13m • 2 changes

Departing Monday, November 9, 2026

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    Arrives next day

    AmtrakAmtrakVIA Rail24h 13m • 2 changes

Frequently asked questions

Want to know about travelling from La Crosse to Buffalo? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from La Crosse to Buffalo.ExpandLaunch map view
  • Distance: 813.8 mi
  • Duration: 24h 13m

What companies run services between La Crosse, WI, USA and Buffalo, NY, USA?

You can take a train from La Crosse Amtrak Station to Buffalo via Chicago Union Station and Buffalo Depew Station in around 17h 52m.

Operators