The average train between La Défense Station and Lyon takes 2h 33m and the fastest train takes 2h 22m. There is a train service every few hours from La Défense Station to Lyon. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between La Défense Station and Lyon. The earliest departure is at 6:00 AM in the morning, and the last departure from La Défense Station is at 8:39 PM which arrives into Lyon at 11:24 PM. All services require a transfer, and take on average 2h 33m. The schedules shown below are for the next available departures.

2h 39m • 1 change

2h 39m • 1 change

2h 29m • 1 change

2h 32m • 1 change

2h 52m • 1 change

2h 31m • 1 change

2h 38m • 1 change

2h 30m • 1 change

2h 52m • 1 change

2h 38m • 1 change

2h 30m • 1 change

2h 30m • 1 change

2h 33m • 1 change

2h 26m • 1 change

2h 25m • 1 change

2h 37m • 1 change
Want to know about travelling from La Défense Station to Lyon? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from La Défense Station to Lyon. However, there are services departing from La Défense Station station and arriving at Lyon station via Lyon Perrache. The journey, including transfers, takes approximately 2h 33m.
La Défense Station to Lyon train services, operated by Réseau Express Régional (RER Paris), depart from Paris Gare De Lyon station.
La Défense Station to Lyon train services, operated by Réseau Express Régional (RER Paris), arrive at Lyon Perrache station.
The distance between La Défense Station and Lyon is 401 km. The road distance is 444 km.
TGV inOui operates a train from Paris Gare De Lyon to Lyon Perrache hourly. Tickets cost €85–140 and the journey takes 2h 10m. Two other operators also service this route.