The average train between La Défense and Brussels takes 2h 1m and the fastest train takes 1h 41m. There is a train service every few hours from La Défense to Brussels. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between La Défense and Brussels. The earliest departure is at 6:22 AM in the morning, and the last departure from La Défense is at 10:59 PM which arrives into Brussels at 7:34 AM. All services require a transfer at Gare Magenta and take an average of 2h 1m. The schedules shown below are for the next available departures.

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Want to know about travelling from La Défense to Brussels? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from La Défense to Brussels. However, there are services departing from La Défense station and arriving at Brussels station via Brussel-Zuid / Bruxelles-Midi. The journey, including transfers, takes approximately 2h 1m.
La Défense to Brussels train services, operated by Société Nationale des Chemins de fer Français (SNCF), depart from Paris Nord station.
La Défense to Brussels train services, operated by Société Nationale des Chemins de fer Français (SNCF), arrive at Brussel-Zuid / Bruxelles-Midi station.
The distance between La Défense and Brussels is 265.1 km. The road distance is 319 km.
Eurostar operates a train from Paris Nord to Brussel-Zuid / Bruxelles-Midi every 20 minutes. Tickets cost €90–160 and the journey takes 1h 29m. Société Nationale des Chemins de fer Français (SNCF) also services this route every 4 hours.