The average train between Livorno and Isernia takes 7h 33m and the fastest train takes 5h 1m. The train service runs several times per day from Livorno to Isernia. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 3 times a day between Livorno and Isernia. The earliest departure is at 9:22 AM in the morning, and the last departure from Livorno is at 8:03 PM which arrives into Isernia at 8:27 AM. All services require a transfer, and take on average 7h 33m. The schedules shown below are for the next available departures.

5h 33m • 1 change

5h 1m • 1 change
Arrives next day

12h 24m • 1 change

6h 1m • 1 change

5h 4m • 1 change
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12h 24m • 1 change

6h 1m • 1 change

5h 4m • 1 change
Arrives next day

12h 24m • 1 change

6h 1m • 1 change

5h 4m • 1 change
Arrives next day

12h 24m • 1 change

6h 1m • 1 change

5h 4m • 1 change
Arrives next day

12h 24m • 1 change
Want to know about travelling from Livorno to Isernia? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Livorno to Isernia. However, there are services departing from Livorno station and arriving at Isernia station via Roma Termini. The journey, including transfers, takes approximately 7h 33m.
Livorno to Isernia train services, operated by Trenitalia Frecce, depart from Livorno Centrale station.
Livorno to Isernia train services, operated by Trenitalia Frecce, arrive at Isernia station.
Book your Livorno to Isernia train tickets online with Trenitalia Frecce and Trenitalia.
The distance between Livorno and Isernia is 386.4 km. The road distance is 498 km.
You can take a train from Livorno Centrale to Isernia via Roma Termini in around 5h 57m.