Lyon to Brussels Central Station Trains

Lyon to Brussels Central Station trains

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Trip Overview

The average train between Lyon and Brussels Central Station takes 4h 33m and the fastest train takes 4h 13m. The train service runs several times per day from Lyon to Brussels Central Station. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

4h 33m
Duration: 752 km
Distance: €185
Average price: 5 times a day
Frequency

Train (TGV)

best

Take the train from Lyon Part Dieu to Brussel-Zuid / Bruxelles-Miditrain Tgv

3h 56m

€158–246

Lyon to Brussels Central Station train times

Trains run 5 times a day between Lyon and Brussels Central Station. The earliest departure is at 5:50 AM in the morning, and the last departure from Lyon is at 7:00 PM which arrives into Brussels Central Station at 11:20 PM. All services require a transfer, and take on average 4h 33m. The schedules shown below are for the next available departures.

Departing Sunday, August 16, 2026

8:27 AM → 12:44 PM
4h 17m • 1 change
11:00 AM → 4:13 PM
5h 13m • 1 change
2:00 PM → 6:44 PM
4h 44m • 1 change
5:00 PM → 9:17 PM
4h 17m • 1 change
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Departing Monday, August 17, 2026

5:50 AM → 10:21 AM
4h 31m • 1 change
11:00 AM → 4:08 PM
5h 8m • 1 change
2:00 PM → 6:44 PM
4h 44m • 1 change
4:59 PM → 9:13 PM
4h 14m • 1 change
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Departing Tuesday, August 18, 2026

5:50 AM → 10:21 AM
4h 31m • 1 change
11:00 AM → 4:08 PM
5h 8m • 1 change
2:00 PM → 6:44 PM
4h 44m • 1 change
4:59 PM → 9:13 PM
4h 14m • 1 change
Show more

Departing Wednesday, August 19, 2026

5:50 AM → 10:21 AM
4h 31m • 1 change
11:00 AM → 4:08 PM
5h 8m • 1 change
2:00 PM → 6:41 PM
4h 41m • 1 change
4:59 PM → 9:13 PM
4h 14m • 1 change
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Departing Thursday, August 20, 2026

5:50 AM → 10:21 AM
4h 31m • 1 change
11:00 AM → 4:08 PM
5h 8m • 1 change
2:00 PM → 6:44 PM
4h 44m • 1 change
4:59 PM → 9:13 PM
4h 14m • 1 change
Show more

Departing Friday, August 21, 2026

5:50 AM → 10:21 AM
4h 31m • 1 change
11:00 AM → 4:08 PM
5h 8m • 1 change
2:00 PM → 6:44 PM
4h 44m • 1 change
4:59 PM → 9:13 PM
4h 14m • 1 change
Show more

Departing Saturday, August 22, 2026

5:50 AM → 10:21 AM
4h 31m • 1 change
8:27 AM → 12:44 PM
4h 17m • 1 change
2:00 PM → 6:44 PM
4h 44m • 1 change
4:58 PM → 9:13 PM
4h 15m • 1 change
Show more

Frequently asked questions

Want to know about travelling from Lyon to Brussels Central Station? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.