The average train between Macclesfield and Plymouth takes 5h 40m and the fastest train takes 4h 56m. There is a train service every few hours from Macclesfield to Plymouth. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Macclesfield and Plymouth. The earliest departure is at 6:47 AM in the morning, and the last departure from Macclesfield is at 10:26 PM which arrives into Plymouth at 10:47 AM. All services require a transfer, and take on average 5h 40m. The schedules shown below are for the next available departures.

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5h • 1 changeWant to know about travelling from Macclesfield to Plymouth? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Macclesfield to Plymouth. However, there are services departing from Macclesfield station and arriving at Plymouth station via Birmingham New Street station. The journey, including transfers, takes approximately 5h 40m.
Macclesfield to Plymouth train services, operated by Cross Country, depart from Macclesfield station.
Macclesfield to Plymouth train services, operated by Cross Country, arrive at Plymouth station.
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The distance between Macclesfield and Plymouth is 349.8 km. The road distance is 418 km.
You can take a train from Macclesfield to Plymouth via Birmingham New Street in around 5h 43m.