The average train between Madrid and Ampuero takes 9h 19m and the fastest train takes 6h 43m. The train service runs several times per day from Madrid to Ampuero. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 3 times a day between Madrid and Ampuero. The earliest departure is at 7:45 AM in the morning, and the last departure from Madrid is at 7:08 PM which arrives into Ampuero at 9:21 AM. All services require a transfer, and take on average 9h 19m. The schedules shown below are for the next available departures.

7h 29m • 1 change

6h 43m • 1 change
Arrives next day

14h 13m • 1 change

7h 29m • 1 change

6h 43m • 1 change
Arrives next day

14h 13m • 1 change

7h 29m • 1 change

6h 43m • 1 change
Arrives next day

14h 13m • 1 change
Want to know about travelling from Madrid to Ampuero? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Madrid to Ampuero. However, there are services departing from Madrid station and arriving at Ampuero station via Santander. The journey, including transfers, takes approximately 9h 19m.
Madrid to Ampuero train services, operated by Renfe Viajeros, depart from Madrid Chamartín station.
Madrid to Ampuero train services, operated by Renfe Viajeros, arrive at Marrón station.
The distance between Madrid and Ampuero is 326.4 km. The road distance is 491 km.
You can take a train from Madrid Chamartín to Marrón via Santander in around 6h 48m.