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Madrid to Brindisi trains

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Trip Overview

The average train between Madrid and Brindisi takes 45h 59m and the fastest train takes 45h 54m. The train runs, on average, 5 times per week from Madrid to Brindisi. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

45h 59m
Duration
2,615 km
Distance
€465
Average price
5 times a week
Frequency

Madrid to Brindisi train times

Trains run 5 times a week between Madrid and Brindisi. The earliest departure is at 8:10 PM in the evening, and the last departure from Madrid is at 8:30 PM which arrives into Brindisi at 6:24 PM. All services require a transfer at Barcelona-Sants and take an average of 45h 59m. The schedules shown below are for the next available departures.

Departing Friday, October 9, 2026

  •  → 

    Arrives +2 days

    Renfe AVETGV inOuiZou! Lignes Express RégionalesTrenitaliaTrenitalia Frecce45h 54m • 4 changes

Departing Saturday, October 10, 2026

  •  → 

    Arrives +2 days

    OuigoTGV inOuiZou! Lignes Express RégionalesTrenitaliaTrenitalia Frecce46h 14m • 4 changes

Departing Sunday, October 11, 2026

  •  → 

    Arrives +2 days

    iryoTGV inOuiZou! Lignes Express RégionalesTrenitaliaTrenitalia Frecce46h 2m • 4 changes

Departing Monday, October 12, 2026

  •  → 

    Arrives +2 days

    Renfe AVETGV inOuiZou! Lignes Express RégionalesTrenitaliaTrenitalia Frecce45h 54m • 4 changes

Departing Tuesday, October 13, 2026

  •  → 

    Arrives +2 days

    Renfe AVETGV inOuiZou! Lignes Express RégionalesTrenitaliaTrenitalia Frecce45h 54m • 4 changes

Frequently asked questions

Want to know about travelling from Madrid to Brindisi? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Madrid to Brindisi.ExpandLaunch map view
  • Distance: 2,614.7 km
  • Duration: 45h 59m

What companies run services between Madrid, Spain and Brindisi, Italy?

You can take a train from Madrid-Puerta de Atocha-Almudena Grandes to Brindisi via Barcelona-Sants, Valence Tgv Rhone-Alpes Sud, Chambery Challes Les Eaux, and Torino Porta Susa in around 24h 27m.

Operators