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Madrid to Brindisi trains

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Trip Overview

The average train between Madrid and Brindisi takes 45h 59m and the fastest train takes 45h 54m. The train runs, on average, 5 times per week from Madrid to Brindisi. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

45h 59m
Duration
2,675 km
Distance
€406
Average price
5 times a week
Frequency

Madrid to Brindisi train times

Trains run 5 times a week between Madrid and Brindisi. The earliest departure is at 8:10 PM in the evening, and the last departure from Madrid is at 8:30 PM which arrives into Brindisi at 6:24 PM. All services require a transfer at Barcelona-Sants and take an average of 45h 59m. The schedules shown below are for the next available departures.

Departing Saturday, October 31, 2026

  •  → 

    Arrives +2 days

    OuigoRenfe ViajerosTrenitaliaTrenitalia Frecce46h 14m • 3 changes

Departing Sunday, November 1, 2026

  •  → 

    Arrives +2 days

    iryoRenfe ViajerosTrenitaliaTrenitalia Frecce46h 2m • 3 changes

Departing Monday, November 2, 2026

  •  → 

    Arrives +2 days

    Renfe AVERenfe ViajerosTrenitaliaTrenitalia Frecce45h 54m • 3 changes

Departing Tuesday, November 3, 2026

  •  → 

    Arrives +2 days

    Renfe AVERenfe ViajerosTrenitaliaTrenitalia Frecce45h 54m • 3 changes

Departing Wednesday, November 4, 2026

  •  → 

    Arrives +2 days

    Renfe AVERenfe ViajerosTrenitaliaTrenitalia Frecce45h 54m • 3 changes

Frequently asked questions

Want to know about travelling from Madrid to Brindisi? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Madrid to Brindisi.ExpandLaunch map view
  • Distance: 2,675.2 km
  • Duration: 45h 59m

What companies run services between Madrid, Spain and Brindisi, Italy?

You can take a train from Madrid-Puerta de Atocha-Almudena Grandes to Brindisi Stazione Centrale via Barcelona-Sants, Lyon Part Dieu, and Torino Porta Susa in around 24h 9m.

Operators