The average train between Madrid and Dos Hermanas takes 3h 42m and the fastest train takes 3h 2m. There is a train service every few hours from Madrid to Dos Hermanas. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Madrid and Dos Hermanas. The earliest departure is at 6:50 AM in the morning, and the last departure from Madrid is at 9:05 PM which arrives into Dos Hermanas at 6:12 AM. All services require a transfer, and take on average 3h 42m. The schedules shown below are for the next available departures.

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3h 13m • 1 changeWant to know about travelling from Madrid to Dos Hermanas? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Madrid to Dos Hermanas. However, there are services departing from Madrid-Puerta de Atocha-Almudena Grandes station and arriving at Sevilla-Santa Justa station via Sevilla-Santa Justa station. The journey, including transfers, takes approximately 3h 42m.
Madrid to Dos Hermanas train services, operated by Renfe AVE, depart from Madrid-Puerta de Atocha-Almudena Grandes station.
Madrid to Dos Hermanas train services, operated by Renfe AVE, arrive at Sevilla-Santa Justa station.
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The distance between Madrid and Dos Hermanas is 397.9 km. The road distance is 533 km.
Renfe AVE operates a train from Madrid-Puerta de Atocha-Almudena Grandes to Sevilla-Santa Justa hourly. Tickets cost €65–120 and the journey takes 2h 39m. Three other operators also service this route.