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Madrid to Lake Iseo trains

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Trip Overview

The train between Madrid and Lake Iseo takes 37h 6m. The train runs, on average, 5 times per week from Madrid to Lake Iseo. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

37h 6m
Duration
1,821 km
Distance
€261
Average price
5 times a week
Frequency

Madrid to Lake Iseo train times

Trains run 5 times a week between Madrid and Lake Iseo. The service departs Madrid at 8:30 PM in the evening, which arrives into Lake Iseo at 09:36:00. All services require a transfer at Barcelona-Sants and take an average of 37h 6m. The schedules shown below are for the next available departures.

Departing Sunday, November 1, 2026

  •  → 

    Arrives +2 days

    Renfe AVERenfe ViajerosTrenitaliaItaloTrenoTrenord37h 6m • 4 changes

Departing Monday, November 2, 2026

  •  → 

    Arrives +2 days

    Renfe AVERenfe ViajerosTrenitaliaItaloTrenoTrenord37h 6m • 4 changes

Departing Tuesday, November 3, 2026

  •  → 

    Arrives +2 days

    Renfe AVERenfe ViajerosTrenitaliaItaloTrenoTrenord37h 6m • 4 changes

Departing Wednesday, November 4, 2026

  •  → 

    Arrives +2 days

    Renfe AVERenfe ViajerosTrenitaliaItaloTrenoTrenord37h 6m • 4 changes

Departing Thursday, November 5, 2026

  •  → 

    Arrives +2 days

    Renfe AVERenfe ViajerosTrenitaliaItaloTrenoTrenord37h 6m • 4 changes

Frequently asked questions

Want to know about travelling from Madrid to Lake Iseo? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Madrid to Lake Iseo.ExpandLaunch map view
  • Distance: 1,821.2 km
  • Duration: 37h 6m

What companies run services between Madrid, Spain and Lake Iseo, Italy?

You can take a train from Madrid-Puerta de Atocha-Almudena Grandes to Sulzano via Barcelona-Sants, Lyon Part Dieu, Milano Centrale, and Brescia in around 17h 23m.

Operators