The average train between Madrid and San Isidro takes 4h 20m and the fastest train takes 3h 24m. The train service runs several times per day from Madrid to San Isidro. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 2 hours between Madrid and San Isidro. The earliest departure is at 6:15 AM in the morning, and the last departure from Madrid is at 8:00 PM which arrives into San Isidro at 7:22 AM. All services require a transfer at Elche Av/Elx Av and take an average of 4h 20m. The schedules shown below are for the next available departures.

3h 49m • 1 change

3h 29m • 1 change

3h 39m • 1 change

4h 10m • 1 change

3h 49m • 1 change

3h 29m • 1 change

3h 39m • 1 change

4h 10m • 1 change

3h 49m • 1 change

3h 29m • 1 change

3h 39m • 1 change

4h 10m • 1 change

3h 49m • 1 change

3h 56m • 1 change

3h 39m • 1 change

3h 55m • 1 change

3h 49m • 1 change

3h 56m • 1 change

3h 39m • 1 change

3h 55m • 1 change
Want to know about travelling from Madrid to San Isidro? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Madrid to San Isidro. However, there are services departing from Madrid station and arriving at San Isidro station via Elche Av/Elx Av. The journey, including transfers, takes approximately 4h 20m.
Madrid to San Isidro train services, operated by Renfe Viajeros, depart from Madrid Chamartín station.
Madrid to San Isidro train services, operated by Renfe Viajeros, arrive at Elche Av/Elx Av station.
Book your Madrid to San Isidro train tickets online with Renfe Viajeros, Renfe Cercanias and 2 other operators.
The distance between Madrid and San Isidro is 350.8 km. The road distance is 465 km.
Ouigo operates a train from Madrid Chamartín to Elche Av/Elx Av every 4 hours. Tickets cost €40–70 and the journey takes 2h 22m. Two other operators also service this route.