The average train between Madrid and Santiponce takes 4h 9m and the fastest train takes 3h 8m. The train service runs several times per day from Madrid to Santiponce. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 3 hours between Madrid and Santiponce. The earliest departure is at 7:05 AM in the morning, and the last departure from Madrid is at 9:05 PM which arrives into Santiponce at 8:09 AM. All services require a transfer, and take on average 4h 9m. The schedules shown below are for the next available departures.

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3h 30m • 1 changeWant to know about travelling from Madrid to Santiponce? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Madrid to Santiponce. However, there are services departing from Madrid-Puerta de Atocha-Almudena Grandes station and arriving at Sevilla-Santa Justa station via Sevilla-Santa Justa station. The journey, including transfers, takes approximately 4h 9m.
Madrid to Santiponce train services, operated by Renfe AVE, depart from Madrid-Puerta de Atocha-Almudena Grandes station.
Madrid to Santiponce train services, operated by Renfe AVE, arrive at Sevilla-Santa Justa station.
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The distance between Madrid and Santiponce is 388.2 km. The road distance is 522 km.
Renfe AVE operates a train from Madrid-Puerta de Atocha-Almudena Grandes to Sevilla-Santa Justa every 2 hours. Tickets cost €65–120 and the journey takes 2h 39m. Three other operators also service this route.