The average train between Madrid and Santiponce takes 4h 7m and the fastest train takes 3h 8m. The train service runs several times per day from Madrid to Santiponce. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 3 hours between Madrid and Santiponce. The earliest departure is at 7:05 AM in the morning, and the last departure from Madrid is at 9:05 PM which arrives into Santiponce at 6:19 AM. All services require a transfer, and take on average 4h 7m. The schedules shown below are for the next available departures.

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3h 30m • 1 changeWant to know about travelling from Madrid to Santiponce? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Madrid to Santiponce. However, there are services departing from Madrid station and arriving at Santiponce station via Sevilla-Santa Justa. The journey, including transfers, takes approximately 4h 7m.
Madrid to Santiponce train services, operated by Renfe Viajeros, depart from Madrid-Puerta de Atocha-Almudena Grandes station.
Madrid to Santiponce train services, operated by Renfe Viajeros, arrive at Sevilla-Santa Justa station.
Book your Madrid to Santiponce train tickets online with Renfe Viajeros, Renfe Cercanias and 3 other operators.
The distance between Madrid and Santiponce is 388.2 km. The road distance is 487 km.
Renfe AVE operates a train from Madrid-Puerta de Atocha-Almudena Grandes to Sevilla-Santa Justa hourly. Tickets cost €70–120 and the journey takes 2h 39m. Three other operators also service this route.