The average train between Mainz, Hauptbahnhof and Berlin takes 5h 4m and the fastest train takes 4h 44m. There is a train service every few hours from Mainz, Hauptbahnhof to Berlin. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Mainz, Hauptbahnhof and Berlin. The earliest departure is at 2:32 AM at night, and the last departure from Mainz, Hauptbahnhof is at 10:42 PM which arrives into Berlin at 6:41 AM. All services require a transfer, and take on average 5h 4m. The schedules shown below are for the next available departures.

4h 51m • 1 change

4h 44m • 1 change

5h 20m • 1 change

4h 44m • 1 change

5h 22m • 1 change

5h 24m • 1 change

4h 44m • 1 change

4h 51m • 1 change

5h 38m • 1 change

5h 28m • 1 change

4h 44m • 1 change

4h 59m • 1 change
Want to know about travelling from Mainz, Hauptbahnhof to Berlin? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Mainz, Hauptbahnhof to Berlin. However, there are services departing from Mainz, Hauptbahnhof station and arriving at Berlin station via Berlin Hbf. The journey, including transfers, takes approximately 5h 4m.
Mainz, Hauptbahnhof to Berlin train services, operated by vlexx, depart from Frankfurt station.
Mainz, Hauptbahnhof to Berlin train services, operated by vlexx, arrive at Berlin Hbf station.
Book your Mainz, Hauptbahnhof to Berlin train tickets online with vlexx, Deutsche Bahn Intercity (DB IC) and 2 other operators.
The distance between Mainz, Hauptbahnhof and Berlin is 455 km. The road distance is 551 km.
Deutsche Bahn Intercity (DB IC) operates a train from Frankfurt to Berlin Hbf hourly. Tickets cost €90–400 and the journey takes 4h 2m.